The microbiome has gained significant attention in the media, with recent Netflix shows like “Hack Your Health: The Secrets of your Gut.” However, the focus often neglects the viruses known as bacteriophages (or phages) that reside in our microbiome. Despite being the most abundant biological entity on Earth, these phages remain largely understudied in their interaction with the bacterial members in our microbiome. Our gut is an ecosystem that must be kept in balance to prevent disease. Can we harness these phages to regulate bacteria in our gut to prevent disease?